Eficacia del plasma rico en plaquetas en procedimientos estéticos no quirúrgicos: revisión sistemática y metaanálisis

Carlos Rios-Gonzalez

doi:10.53732/rccsalud/e8896

Authors

Carlos Rios-Gonzalez Universidad Sudamericana, Facultad de Ciencias de la Salud, Saltos del Guairá, Paraguay https://orcid.org/0000-0001-7558-8206

DOI:

https://doi.org/10.53732/rccsalud/e8896

Keywords:

platelet-rich plasma, aesthetic medicine, alopecia, facial rejuvenation, meta-analysis

Abstract

Introduction. Platelet-rich plasma (PRP) is a promising autologous biological product widely used in aesthetic medicine. Its application for facial rejuvenation, alopecia, and scar remodeling has shown variable outcomes in clinical studies. Objective. To assess the effectiveness and safety of PRP in non-surgical aesthetic procedures based on clinical trial evidence. Materials and Methods. A systematic review and meta-analysis were conducted following PRISMA guidelines. Five databases were searched for studies published between 2014 and 2025. Randomized controlled trials (RCTs) evaluating PRP in adult patients undergoing non-surgical aesthetic treatments were included. Risk of bias was assessed using Cochrane RoB 2.0, and data were synthesized using fixed-effects models when heterogeneity was low. Results. Four RCTs met inclusion criteria. PRP demonstrated a statistically significant improvement in hair density (mean difference: 26.4 ± 6.2 units/cm²) and subjective facial texture improvement up to 35%. The pooled standardized mean difference (SMD) was 1.17 (95% CI: 0.51–1.84; p < 0.001). No serious adverse events were reported. Conclusion. PRP is an effective and safe option for treating androgenetic alopecia and facial rejuvenation in non-surgical aesthetic medicine. Standardization of protocols and long-term follow-up studies are warranted.

References

Marx RE. Plasma rico en plaquetas: evidencia que apoya su uso. J Oral Maxillofac Surg. 2004;62(4):489–96. https://doi.org/10.1016/j.joms.2003.12.003

Gupta S, Paliczak A, Delgado D. Evidence-based indications of platelet-rich plasma therapy. Expert Rev Hematol. 2021;14(1):97-108. https://doi.org/10.1080/17474086.2021.1860002

Sclafani AP. Aplicaciones de la matriz de fibrina rica en plaquetas en cirugía estética facial. Facial Plast Surg Clin North Am. 2011;19(1):145–51. https://doi.org/10.1016/j.fsc.2010.10.007

Banihashemi M, Zabolinejad N, Salehi M, Hamidi Alamdari D, Nakhaizadeh S. Platelet-rich Plasma use for facial rejuvenation: a clinical trial and review of current literature. Acta Biomed. 2021;92(2):e2021187. https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9687

Samadi P, Sheykhhasan M, Khoshinani HM. The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic Plast Surg. 2019;43(3):803-814. https://doi.org/10.1007/s00266-018-1293-9

Chuah SY, Tan CH, Wang ECE, Tan KT, Chan RKW, Zhao X, et al. Efficacy of platelet-rich plasma in Asians with androgenetic alopecia: A randomized controlled trial. Indian J Dermatol Venereol Leprol. 2023;89(1):135-138. https://doi.org/10.25259/IJDVL_512_2021

Alam M, Hughart R, Champlain A, Geisler A, Paghdal K, Whiting D, et al. Effect of platelet-rich plasma injection for rejuvenation of photoaged facial skin: a randomized clinical trial. JAMA Dermatol. 2018;154(12):1447-1452. https://doi.org/10.1001/jamadermatol.2018.3977

Ghafoor R, Saher N, Ali SM. The Role of 5% Minoxidil versus Platelet-Rich Plasma in Treatment of Alopecia Areata. J Coll Physicians Surg Pak. 2024;34(6):650-653. https://doi.org/10.29271/jcpsp.2024.06.650

Alves R, Grimalt R. Randomized placebo-controlled, double-blind, half-head study to assess the efficacy of platelet-rich plasma on the treatment of androgenetic alopecia. Dermatol Surg. 2016;42(4):491-7. https://doi.org/10.1097/DSS.0000000000000665

Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, Seo YJ, Lee YH, Lee JH, Lee Y. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7 Pt 1):1040-6. https://doi.org/10.1111/j.1524-4725.2012.02394.x

Gentile P, Garcovich S, Bielli A, Scioli MG, Orlandi A, Cervelli V. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial. Stem Cells Transl Med. 2015;4(11):1317-23. https://doi.org/10.5966/sctm.2015-0107

Gentile P, Garcovich S. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy. Int J Mol Sci. 2020;21(8):2702. https://doi.org/10.3390/ijms21082702

Wu WS, Chen LR, Chen KH. Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body. Int J Mol Sci. 2025;26(21):10804. https://doi.org/10.3390/ijms262110804

Asubiaro J, Avajah F. Platelet-Rich Plasma in Aesthetic Dermatology: Current Evidence and Future Directions. Cureus. 2024;16(8):e66734. https://doi.org/10.7759/cureus.66734

Davies C, Miron RJ. Autolougous platelet concentrates in esthetic medicine. Periodontol 2000. 2025;97(1):363-419. https://doi.org/10.1111/prd.12582 .

Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg. 2014;7(2):107-10. https://doi.org/10.4103/0974-2077.138352

Du D, Liang Y. A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20(1):57. https://doi.org/10.1186/s13018-024-05429-w

Altalbawy FMA, Mukhlif BAM, Hussen A, Mohammed JS, S RJ, Singh A, et al. Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights. Regen Ther. 2025;30:278-298. https://doi.org/10.1016/j.reth.2025.06.008