Desarrollo galénico de un gel a base de Magnolia officinalis con propiedades antimicrobianas para el tratamiento del acné

Rocio Belén Martinez Duarte; Sonia Lorena Fretes de Aquino; Maria Paz Cáceres Villalba; Margarita Aguilera de Almada; Lourdes Raquel Samaniego Silva; Gladys Mabel Maidana de Larroza

doi:10.53732/rccsalud/2025.e7122

Authors

Rocio Belén Martinez Duarte Universidad del Nacional de Asunción, Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0009-0008-0743-4326
Sonia Lorena Fretes de Aquino Universidad del Nacional de Asunción, Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0000-0002-3219-2233
Maria Paz Cáceres Villalba Universidad del Nacional de Asunción; Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0000-0003-0877-2972
Margarita Aguilera de Almada Universidad del Nacional de Asunción; Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0000-0003-2952-7925
Lourdes Raquel Samaniego Silva Universidad del Nacional de Asunción, Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0000-0002-1769-3830
Gladys Mabel Maidana de Larroza Universidad del Nacional de Asunción; Facultad de Ciencias Químicas. San Lorenzo, Paraguay https://orcid.org/0000-0001-7094-6254

DOI:

https://doi.org/10.53732/rccsalud/2025.e7122

Keywords:

antimicrobials, Magnolia officinalis, acne, gels

Abstract

Introduction. Acne is a highly prevalent multifactorial inflammatory disease whose conventional treatment with antibiotics and retinoids is limited by adverse effects, bacterial resistance, and poor adherence. This drives the search for safer and more effective alternatives, such as natural products. Magnolia officinalis contains honokiol and magnolol, compounds with documented antimicrobial and anti-inflammatory activity. Developing topical formulations like gels can optimize their cutaneous delivery, improve stability, and facilitate application on oily or acne-prone skin. Objective. To develop and characterize a topical gel based on Magnolia officinalis extract with antimicrobial properties for acne treatment.
Materials and Methods. Three gel variants with different excipient ratios were formulated, selecting the optimal one based on physicochemical and organoleptic parameters. Quality controls (pH, viscosity, density, TLC) were performed, and antimicrobial activity was evaluated against Staphylococcus aureus ATCC 25923 using disk and well diffusion methods. Results. The selected formulation showed pH 5.5, viscosity of 159.7 cP, density of 1.039 g/mL, and positive identification of the extract by TLC. Antimicrobial testing recorded average inhibition halos of 9.6 mm (disks) and 10.6 mm (wells) against S. aureus. Conclusion. The gel developed with Magnolia officinalis showed suitable physicochemical properties and good in vitro antibacterial activity against S. aureus, suggesting its potential as a natural, safe, and sustainable topical alternative for acne management.

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